Methyl Salicylate → N-Propylsalicylamide

HRID 593456

반응식

[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH2:12]([NH2:15])[CH2:13][CH3:14]>>[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:15][CH2:12][CH2:13][CH3:14])=[O:6]

참가 물질

반응물 2

HCID 4133Methyl Salicylate

HCID 7852Propylamine

생성물 1

HCID 81966N-Propylsalicylamide수율 84%

반응 조건

온도: 80 °C

실험 절차

The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.

후처리

concentrationThe reaction mixture was concentrated under reduced pressure
customto give the crude material that
customwas purified by silica gel flash column chromatography

출처 및 근거

ORD 기록: ord-4bf1486374c54440889cb13a2d5c8637
출처 데이터셋: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09242964B2

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