Hydrochloric Acid → (6-methoxynaphthalen-2-yl)methanol

HRID 594321노트

반응식

HRID 594321 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]=[O:14])[CH:7]=[CH:6]2.[BH4-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][OH:14])[CH:7]=[CH:6]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 769916-Methoxy-2-naphthaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 10012701(6-methoxynaphthalen-2-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of commercially available 6-methoxy-2-naphthaldehyde (200 mg; 1.07 mmol) in MeOH (5 ml) was treated portionwise at rt with NaBH4 (50 mg; 1.31 mmol), and the resulting mixture was further stirred at rt, under nitrogen, for 1 h. 2 M aq. HCl was added, and the organic solvent was removed under reduced pressure. AcOEt and water were added, and the separated organic layer was dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure affording (6-methoxynaphthalen-2-yl)methanol as a colorless solid. LC-MS (conditions E): tR=0.55 min.; no ionisation.

후처리

  1. customthe organic solvent was removed under reduced pressure
  2. additionAcOEt and water were added
  3. dry with materialthe separated organic layer was dried over anh. MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-1be3265d43d042ee96a7d9f08bf7dd1a
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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