2-Hydroxyacetohydrazide → HCID 21450833, 화합물

HRID 596353

반응식

HRID 596353 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[NH:13][C:12](=S)[CH2:11][N:10]=[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:8]=2[CH:22]=1)([O-:3])=[O:2].[OH:23][CH2:24][C:25]([NH:27][NH2:28])=O>C(O)CCC>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:25]([CH2:24][OH:23])=[N:27][N:28]=[C:12]3[CH2:11][N:10]=[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:8]=2[CH:22]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 3505362-HydroxyacetohydrazideHCID 123714345-(2-fluorophenyl)-7-nitro-3H-1,4-benzodiazepine-2(1H)-thione

생성물 1

HCID 21450833HCID 21450833, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

In the manner given in Preparation 1, a solution of 1,3-dihydro-7-nitro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol is heated to reflux with hydroxyacetic acid hydrazide to give 8-nitro-1-(hydroxymethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 4 8-(Trifluoromethyl)-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

후처리

  1. customIn the manner given in Preparation 1

출처 및 근거

ORD 기록
ord-713044aba8ad421e9e09ffbb5fc874dd
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04010177

연결된 노트

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