Water → 5-(3,7,11,15-Tetramethylhexadecyloxy)-2-furoic acid

HRID 596633

반응식

HRID 596633 반응식
[CH3:1][CH:2]([CH2:6][CH2:7][CH2:8][CH:9]([CH3:21])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:3][CH2:4][OH:5].[H-].[Na+].Cl[C:25]1[O:29][C:28]([C:30]([OH:32])=[O:31])=[CH:27][CH:26]=1.O>C1(C)C=CC=CC=1>[CH3:1][CH:2]([CH2:6][CH2:7][CH2:8][CH:9]([CH3:21])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:3][CH2:4][O:5][C:25]1[O:29][C:28]([C:30]([OH:32])=[O:31])=[CH:27][CH:26]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 102459DihydrophytolHCID 2348535-Chlorofuran-2-carboxylic acid

생성물 1

HCID 214504315-(3,7,11,15-Tetramethylhexadecyloxy)-2-furoic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 59.8 g (0.2 mole) of 3,7,11,15-tetramethyl-1-hexadecanol and 19.2 g (0.4 mole) of sodium hydride (50% in oil) in 1 liter of toluene is refluxed with stirring for 2 hours then cooled to room temperature. To the mixture 29.3 g (0.2 mole) of 5-chloro-2-furoic acid is added and the mixture is refluxed with stirring for 24 hours. Upon cooling to room temperature the mixture is acidified with glacialacetic acid and water is added. The toluene layer is evaporated and allowed to crystallize to give 5-(3,7,11,15-tetramethylhexadecyloxy)-2-furoic acid.

후처리

  1. temperatureis refluxed
  2. temperaturethe mixture is refluxed
  3. stirringwith stirring for 24 hours
  4. temperatureUpon cooling to room temperature the mixture
  5. additionis added
  6. customThe toluene layer is evaporated
  7. customto crystallize

출처 및 근거

ORD 기록
ord-fd13263df78048ae968f86bbe42ce2d6
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04011334

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