Chloroform → 1-(Bromomethyl)-4-chloro-2-nitrobenzene

HRID 597135

반응식

HRID 597135 반응식
[N+:1]([C:4]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:5]=1[CH2:6]O)([O-:3])=[O:2].C(Cl)(Cl)Cl.P(Br)(Br)[Br:18]>O>[N+:1]([C:4]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:5]=1[CH2:6][Br:18])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 24614Phosphorus tribromideHCID 899564-Chloro-2-nitrobenzyl alcohol

생성물 1

HCID 105868161-(Bromomethyl)-4-chloro-2-nitrobenzene수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 16.5 g. of 2-nitro-4-chlorobenzyl alcohol in 200 ml. of chloroform was added dropwise 13 g. of phosphorus tribromide, and the mixture was heated to reflux for 1 hour on a water bath. The reaction mixture was then poured into water, and the chloroform layer was separated and washed with water. After the solvent was removed, the residue was extracted with ligroin while warming and allowed to stand to form colorless acicular crystals of 2-nitro-4-chlorobenzyl bromide (80% yield) melting at 42° to 43° C.

후처리

  1. temperatureto reflux for 1 hour on a water bath
  2. customthe chloroform layer was separated
  3. washwashed with water
  4. customAfter the solvent was removed
  5. extractionthe residue was extracted with ligroin
  6. temperaturewhile warming

출처 및 근거

ORD 기록
ord-a0537214ec96402ca5b697f29eb4e3a1
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04013639

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