Water → 2,3-Dicarbomethoxycyclobutyl phenyl sulfone

HRID 5973

반응식

HRID 5973 반응식
[C:1]1([S:7][CH:8]2[CH2:11][CH:10]([C:12]([O:14][CH3:15])=[O:13])[CH:9]2[C:16]([O:18][CH3:19])=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:20]OS([O-])=O.[K+].[K+].S(=O)(=O)([O-])[O-].[K+].S([O-])(OO)(=O)=O.[K+].[OH2:40]>CO.ClC(Cl)C>[C:1]1([S:7]([CH:8]2[CH2:11][CH:10]([C:12]([O:14][CH3:15])=[O:13])[CH:9]2[C:16]([O:18][CH3:19])=[O:17])(=[O:20])=[O:40])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

8

반응물 5

HCID 962Water2회HCID 24507Potassium SulfateHCID 19794294Dimethyl 3-(phenylthio)cyclobutane-1,2-dicarboxylateHCID 23707502Potassium hydroxy sulfiteHCID 23712892Potassium peroxymonosulfate

생성물 1

HCID 197942682,3-Dicarbomethoxycyclobutyl phenyl sulfone수율 94%

시약·촉매·용매 2

HCID 887Methanol용매HCID 63651,1-Dichloroethane용매

실험 절차

To a vigorously stirred solution of 1.05 g (3.75 mmol) of dimethyl 3-(phenylthio)cyclobutane-1,2-dicarboxylate from Step A in 20 mL of methanol, was added slowly a suspension of 3.46 g (11.25 mmol) of OXONE (a commercially available mixture of sulfuric acid potassium salt and potassium hydrogen peroxymonosulfate) in 20 mL of water. The resultant cloudy suspension was stirred for 0.5 h then diluted with 50 mL of water and 100 mL of 1,2=dichloroethane. The phases were allowed to separate and the aqueous phase was extracted with 20 mL of 1,2-dichloroethane. The combined organic layers were washed with 2×50 mL of dilute aqueous sodium bicarbonate solution, 2×50 mL of water and 50 mL of brine, dried over anhydrous magnesium sulfate and concentrated to give 1.10 g (94% yield) of the title compound as a viscous oil; EI-MS, m/e (relative intensity): 281 (M+ --OCH3, 9), 171 (100), 139 (24), 111 (47); 1H NMR (CDCl3) δ2.48 (m, 1H), 2.76 (m, 1H), 3.23 (q, 1H), 3.52 (s, 3H), 3.74 (s, 3H), 3.80 (m, 1H), 3.92 (q, 1H), 7.58 (m, 2H), 7.68 (m, 1H), 7.89 (m, 2H).

후처리

  1. customto separate
  2. extractionthe aqueous phase was extracted with 20 mL of 1,2-dichloroethane
  3. washThe combined organic layers were washed with 2×50 mL of dilute aqueous sodium bicarbonate solution, 2×50 mL of water and 50 mL of brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-70dbc0e828674b098de600e6c942e203
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246931

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