Bromoacetyl bromide → 1-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline

HRID 597705노트

반응식

HRID 597705 반응식
[Br:1][CH2:2][C:3](Br)=[O:4].[NH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1>C1C=CC=CC=1>[Br:1][CH2:2][C:3]([N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)=[O:4]

참가 물질

4

반응물 2

HCID 61147Bromoacetyl bromideHCID 694601,2,3,4-Tetrahydroquinoline

생성물 1

HCID 5838141-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a stirred solution of 20.2 g. of bromoacetyl bromide in 150 ml. of benzene is added dropwise over 30 minutes, 26.6 g. of 1,2,3,4-tetrahydroquinoline dissolved in 35 ml. of benzene. The reaction mixture is then stirred at room temperature for 18 hours, after which time the precipitate is filtered off. The resultant filtrate is washed successively with 1N HCL solution and with a saturated sodium chloride solution, dried, and the solvent removed under reduced pressure to yield 1-(bromoacetyl)-1,2,3,4-tetrahydroquinoline, b.p. 70°-80° C. (at 0.1 mm. Hg).

후처리

  1. filtrationafter which time the precipitate is filtered off
  2. washThe resultant filtrate is washed successively with 1N HCL solution and with a saturated sodium chloride solution
  3. customdried
  4. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-ce6c420f2dd44392ad412c7d98e22342
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04015005

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