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ClC1C=CC2N=C(NC3CCNC3)OC=2C=1.Cl.Cl[C:19]1[N:28]=[CH:27][C:26]2[C:21](=[CH:22][C:23]([Cl:29])=[CH:24][CH:25]=2)[N:20]=1.C(OC([N:37]1[CH2:42][CH2:41][CH2:40][CH:39]([NH2:43])[CH2:38]1)=O)(C)(C)C>>[Cl:29][C:23]1[CH:22]=[C:21]2[C:26]([CH:27]=[N:28][C:19]([NH:43][CH:39]3[CH2:40][CH2:41][CH2:42][NH:37][CH2:38]3)=[N:20]2)=[CH:25][CH:24]=1참가 물질
5
실험 절차
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine; hydrochloride (example 1, step 1) the title compound was prepared from 2,7-dichloro-quinazoline (Synthesis 1978, 5, 379-82) and 3-Amino-piperidine-1-carboxylic acid tert-butyl ester (commercially available) and subsequent cleavage of the tert-butyl oxy carbonyl protecting group under acidic conditions. (MH+) 263.1.
출처 및 근거
- ORD 기록
- ord-b52b91ea5590466395e053fadafa4283
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07897627B2
연결된 노트
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