Potassium Carbonate → 2-Bromo-4-methyl-3-nitro-pyridine
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=O)[C:3]=1[N+:9]([O-:11])=[O:10].P(Br)(Br)([Br:14])=O.C(=O)([O-])[O-].[K+].[K+]>ClC(Cl)C>[Br:14][C:4]1[C:3]([N+:9]([O-:11])=[O:10])=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=1참가 물질
5
실험 절차
The 4-methyl-3-nitropyridin-2(1H)-one (110 g, 0.71 mol) was suspended in dichloroethane (1 L). The solution of phosphorus oxybromide (317 g, 1.1 mol) in dichloroethane (1 L) was added dropwise thereto at the ambient temperature. The reaction mixture was refluxed for 12 hours. The mixture was allowed to cool to room temperature, poured into ice water, and neutralized with potassium carbonate. The organic layer was separated, washed with water and brine, and dried over sodium sulfate. The solvent was evaporated to provide the title compound (yield 71.8%).
후처리
- customat the ambient temperature
- temperatureThe reaction mixture was refluxed for 12 hours
- customThe organic layer was separated
- washwashed with water and brine
- dry with materialdried over sodium sulfate
- customThe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-ebac018909a54f20af991c206b66b15b
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09440968B2
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