Hydrochloric Acid → 4-Chloro-benzaldehyde oxime

HRID 600715

반응식

HRID 600715 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.Cl.[NH2:11][OH:12].N1C=CC=CC=1.Cl>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:11][OH:12])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 77264-ChlorobenzaldehydeHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 2191584-Chloro-benzaldehyde oxime

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Chlorobenzaldehyde (45.6 g; 0.325 mol), hydroxylamine hydrochloride (27.9 g; 0.401 mol) and pyridine (64 mL; 0.791 mol) in methylene chloride (600 mL) were stirred overnight at room temperature. The reaction mixture was poured into aqueous hydrochloric acid (2N; 300 mL) and extracted. The organic layer was washed with additional aqueous hydrochloric acid (2×300 mL), water (300 mL), dried (MgSO4), filtered and evaporated to yield oxime 1a as a white solid.

후처리

  1. extractionextracted
  2. washThe organic layer was washed with additional aqueous hydrochloric acid (2×300 mL), water (300 mL)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-dec01e3068d14e62ad5b13417df02795
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902227B2

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