Sodium Hydroxide → 5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine
반응식
[N:1]1([C:6]2[CH:7]=[C:8]([C:16]3[S:20][C:19]([NH:21]C(=O)C)=[N:18][C:17]=3[CH3:25])[CH:9]=[CH:10][C:11]=2[S:12]([CH3:15])(=[O:14])=[O:13])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Na+]>Cl>[N:1]1([C:6]2[CH:7]=[C:8]([C:16]3[S:20][C:19]([NH2:21])=[N:18][C:17]=3[CH3:25])[CH:9]=[CH:10][C:11]=2[S:12]([CH3:15])(=[O:14])=[O:13])[CH:5]=[CH:4][N:3]=[CH:2]1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
N-[5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (AF2) (5.0 g, 13 mmol) is dissolved in 7M HCl (50 ml) and the solution is heated at 100° C. for 3 h. When cool the solution is brought to pH 8 by addition of aqueous NaOH whereupon the titled product precipitates. This is washed with ethanol followed by EtOAc, Et2O and dried.