2-(tert-Butylamino)ethanol → 1-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol

HRID 603260

반응식

HRID 603260 반응식
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:12][O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:13]([NH:17][CH2:18][CH2:19][OH:20])([CH3:16])([CH3:15])[CH3:14]>C(O)C>[CH2:1]([O:8][CH2:9][CH:10]([OH:11])[CH2:12][N:17]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:18][CH2:19][OH:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 783612-(tert-Butylamino)ethanolHCID 94247Benzyl glycidyl ether

생성물 1

HCID 576568621-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol수율 83.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-[(benzyloxy)methyl]oxirane (350 mg) and 2-(tert-butylamino)ethanol (500 mg) in ethanol (20 mL) was heated to reflux temperature and left at this temperature overnight. The solution was concentrated at reduced pressure. The residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane. This gave the title compound as a colourless oil (501 mg)

후처리

  1. temperatureto reflux temperature
  2. concentrationThe solution was concentrated at reduced pressure
  3. filtrationThe residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane

출처 및 근거

ORD 기록
ord-006fedb16250481cbc8dc74c7ccb5e7b
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906645B2

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