Azobisisobutyronitrile → 5-Bromo-4-(bromomethyl)-2-phenyl-1,3-thiazole
반응식
[Br:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH3:13].C1C(=O)N([Br:21])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][Br:21]참가 물질
5
실험 절차
A mixture of 5-Bromo-4-methyl-2-phenyl-1,3-thiazole (1.00 g, 3.93 mmol), NBS (0.84 g, 4.72 mmol) and catalytic amount of AIBN in CCl4 (20 mL) was heated at reflux for 24 h. No starting material was seen by 1H NMR. The solvent was removed. The title compound was obtained as a colorless solid after flash chromatography using EtOAc/hexane (3:97) as the eluant. 1H NMR (500 MHz, CDCl3): δ 7.90 (m, 3H), 7.48 (m, 2H), 4.61 (s, 2H).
후처리
- temperaturewas heated
- temperatureat reflux for 24 h
- customThe solvent was removed
출처 및 근거
- ORD 기록
- ord-466915342bb04b1bb10b725b02990c3b
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07910592B2
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