Sodium hydride → HCID 178462378, 화합물

HRID 60531노트

반응식

HRID 60531 반응식
[H-].[Na+].[BH4-].[Na+].O.[NH2:6][C:7]1[N:12]=[C:11]([SH:13])[N:10]=[C:9]([OH:14])[CH:8]=1.Cl[C@@H:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:17]>CN(C=O)C>[NH2:6][C:7]1[N:12]=[C:11]([S:13][C@H:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[N:10]=[C:9]([OH:14])[CH:8]=1

참가 물질

6

반응물 4

HCID 24758Sodium hydrideHCID 642190((1R)-1-Chloroethyl)benzeneHCID 4311764Sodium borohydrideHCID 178507962HCID 178507962, 화합물

생성물 1

HCID 178462378HCID 178462378, 화합물수율 46.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

NaH (60% in oil) (0.5 g, 12.5 mmol) followed by NaBH4 (40 mg, 1 mmol) was added to 6-amino-2-mercaptopyrimidin-4-ol monohydrate (1.6 g, 10 mmol) in DMF (20 mL). After 30 min, [(1R)-1-chloroethyl]benzene (1.4 g, 10 mmol) was added and the reaction mixture was stirred for 16 h. The reaction was concentrated in vacuo to ca. 10 mL volume and then poured into water (ca. 50 mL). The precipitated solid material was filtered off and washed with water and ether to give the title compound (1.15 g, 46% yield).

후처리

  1. concentrationThe reaction was concentrated in vacuo to ca. 10 mL volume
  2. additionpoured into water (ca. 50 mL)
  3. filtrationThe precipitated solid material was filtered off
  4. washwashed with water and ether

출처 및 근거

ORD 기록
ord-fe4087e49a5f4d0798cd54d0f8e0d74f
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440992B2

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