Hydrochloric Acid → 5-Chloro-4-nitrothiophene-2-carboxylic acid

HRID 605316노트

반응식

HRID 605316 반응식
C([O:3][C:4]([C:6]1[S:7][C:8]([Cl:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])C.[OH-].[Li+].Cl>CO.O>[Cl:14][C:8]1[S:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][C:9]=1[N+:11]([O-:13])=[O:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 56763846HCID 56763846, 화합물

생성물 1

HCID 132055635-Chloro-4-nitrothiophene-2-carboxylic acid

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

The product from Example 351A (1 equiv) was dissolved in a methanol/water 3/1 mixture followed by the addition of lithium hydroxide (5 equiv). The resultant solution was stirred at room temperature for 24 hours followed by the addition of 1N aqueous hydrochloric acid until the solution was a pH of 2. The mixture was then extracted with ethyl acetate, the organic extracts dried and concentrated under vacuum to provide the title product.

후처리

  1. extractionThe mixture was then extracted with ethyl acetate
  2. customthe organic extracts dried
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-8671b14d8ae14514951ecdd76cc41574
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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