Hydrochloric Acid → 6-Hydroxyhexanoic Acid

HRID 605444

반응식

HRID 605444 반응식
[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-:9].[K+].CO.Cl>C1COCC1>[OH:9][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 10401epsilon-CAPROLACTONEHCID 14797Potassium Hydroxide

생성물 1

HCID 144906-Hydroxyhexanoic Acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Caprolactone (100 g) was added to a mixture of potassium hydroxide (145 g), methanol (110 mL), and THF (390 mL). The resulting mixture was stirred at room temperature overnight. The solution was then acidified with HCl and extracted with ethyl acetate. The combined organic layers were washed with water, dried, filtered, and concentrated to obtain 6-hydroxyhexanoic acid. 1H NMR (CDCl3, 500 MHz) δ 1.44 (m, 2H), 1.60 (m, 2H), 1.68 (m, 2H), 2.37 (t, J=7.5 Hz, 2H), 3.66 (t, J=6.5 Hz, 2H), 5.80 (br, 1H).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with water
  3. customdried
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a8a9cabd6aea49d386907d8f1deaf117
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07914700B2

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