(4-(Cyclopentylcarbamoyl)phenyl)boronic acid → Biphenyl

HRID 608095

반응식

HRID 608095 반응식
CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21.O=C(NC1CCCC1)c1ccc(B(O)O)cc1.O=P(O)(O)O.[K]>CC(C)c1cc(C(C)C)c(-c2ccccc2[PH](C2CCCCC2)(C2CCCCC2)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)c(C(C)C)c1.CS(C)=O.O>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(-c3ccc(C(=O)NC4CCCC4)cc3)c(C)cc21

참가 물질

9

반응물 2

HCID 2773358(4-(Cyclopentylcarbamoyl)phenyl)boronic acidHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

생성물 3

HCID 7095BiphenylHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylateHCID 178474758HCID 178474758, 화합물

시약·촉매·용매 4

HCID 178439024HCID 178439024, 화합물촉매HCID 679Dimethyl Sulfoxide용매3회HCID 962Water용매2회HCID 16218557Phosphoric acid (potassium)기타

후처리

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

출처 및 근거

ORD 기록
ord-f643ae0d25e74225a31947cb95504bb4
출처 데이터셋
Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
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