Aniline → 3-Nitrobenzanilide

HRID 610074

반응식

HRID 610074 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[N+:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](Cl)=[O:22])([O-:17])=[O:16].C(=O)(O)[O-].[Na+]>ClCCl>[N+:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:22])([O-:17])=[O:16]

참가 물질

6

반응물 4

HCID 6115AnilineHCID 8471TriethylamineHCID 8495Benzoyl chloride, 3-nitro-HCID 516892Sodium Bicarbonate

생성물 1

HCID 3477553-Nitrobenzanilide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a cooled (0° C.) solution of aniline (17 g, 180 mmol) and triethylamine (27 mL, 190 mmol) in dichloromethane (100 mL) was added a solution of 3-nitrobenzoyl chloride (30 g, 160 mmol) in dichloromethane (60 mL). The mixture was stirred for 15 min at 0° C. then overnight at room temperature. It was then poured into saturated sodium bicarbonate (1 L) and stirred vigorously for 15 min. The precipitate was collected, washed with water and dried (40 g, 100%).

후처리

  1. customovernight
  2. customat room temperature
  3. stirringstirred vigorously for 15 min
  4. customThe precipitate was collected
  5. washwashed with water
  6. customdried (40 g, 100%)

출처 및 근거

ORD 기록
ord-68e152fdc1f3477bba21a2bec2bf8b0b
출처 데이터셋
uspto-grants-1999_12
특허 번호
US05998463

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