Water → 2-Methoxy-6-methylbenzoic acid

HRID 611716

반응식

HRID 611716 반응식
[CH3:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[C:6]([O:13][CH3:14])[CH:5]=[CH:4][CH:3]=1.O.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([O:13][CH3:14])[CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 5910602-Methoxy-6-methyl-benzoic acid ethyl ester

생성물 1

HCID 2731702-Methoxy-6-methylbenzoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 6-methyl-2-methoxybenzoate (642.0 g, 3.3 mol), water (2.5 l), ethanol (4.0 l) and sodium hydroxide (270 g, 6.6 mol) is heated under reflux with stirring for 20 hours. Subsequently, ethanol is distilled off and the reaction mixture is diluted with water, acidified with concentrated hydrochloric acid. The solid material is collected by vacuum filtration, washed with water and dried yielding off-white crystals, 460.0 g (83.9%).

후처리

  1. temperatureis heated
  2. temperatureunder reflux
  3. distillationSubsequently, ethanol is distilled off
  4. additionthe reaction mixture is diluted with water
  5. filtrationThe solid material is collected by vacuum filtration
  6. washwashed with water
  7. customdried
  8. customyielding off-white crystals, 460.0 g (83.9%)

출처 및 근거

ORD 기록
ord-52785138e4334a1d99244b55c52f6e0d
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06001883

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