Hydrochloric Acid → 4-Amino-8-(2,6-dichlorobenzoylamino)quinoline

HRID 613576노트

반응식

HRID 613576 반응식
[Cl:1][C:2]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][CH:13]=[C:12]2[N:17]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:5].Cl.[OH-].[Na+]>C(O)(=O)C>[NH2:17][C:12]1[C:11]2[C:16](=[C:7]([NH:6][C:4](=[O:5])[C:3]3[C:2]([Cl:1])=[CH:40][CH:39]=[CH:38][C:37]=3[Cl:41])[CH:8]=[CH:9][CH:10]=2)[N:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 195929798-(2,6-Dichlorobenzoylamino)-4-[(triphenylphosphoranylidene)amino]quinoline

생성물 1

HCID 195925244-Amino-8-(2,6-dichlorobenzoylamino)quinoline수율 100.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
130 °C

실험 절차

A mixture of 8-(2,6-dichlorobenzoylamino)-4-[(triphenylphosphoranylidene)amino]quinoline (310 mg), 6N hydrochloric acid (5 ml) and acetic acid (5 ml) was heated for 3 hours at 130° C. After cooling, the mixture was neutralized with 6N sodium hydroxide solution, and the insoluble material was collected by filtration. The residue was recrystallized from ethyl acetate to give 4-amino-8-(2,6-dichlorobenzoylamino)quinoline (174 mg).

후처리

  1. temperatureAfter cooling
  2. filtrationthe insoluble material was collected by filtration
  3. customThe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-d2585a3889fd4f3a9d430e42359e0a3e
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008230

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