Hydrochloric Acid → 3-Bromo-8-hydroxy-2-methylimidazo[1,2-a]pyridine
반응식
C([O:4][C:5]1[C:6]2[N:7]([C:11]([Br:15])=[C:12]([CH3:14])[N:13]=2)[CH:8]=[CH:9][CH:10]=1)(=O)C.[OH-].[Na+].Cl>CO>[Br:15][C:11]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:5]([OH:4])[C:6]2=[N:13][C:12]=1[CH3:14]참가 물질
5
실험 절차
To a solution of 8 -acetoxy-3-bromo-2-methylimidazo[1,2-a]pyridine (235 mg) in methanol (2.5 ml) was added 1N sodium hydroxide solution (2.0 ml) under ice-cooling, and the mixture was stirred for 30 minutes at the same temperature. The mixture was neutralized with 1N hydrochloric acid, and the resulting precipitates were collected by filtration and washed with water to give 3-bromo-8-hydroxy-2-methylimidazo[1,2-a]pyridine (150 mg) as brown powder.
후처리
- temperaturecooling
- customthe resulting precipitates
- filtrationwere collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-fcb8a08985eb4b4f9663ae54a94945aa
- 출처 데이터셋
- uspto-grants-1999_12
- 특허 번호
- US06008229
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