Hydrochloric Acid → Fenoprofen Ethyl Ester

HRID 614657

반응식

HRID 614657 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH-].[Na+].[CH2:22](O)[CH3:23]>>[O:1]([C:8]1[CH:9]=[C:10]([CH:14]([CH3:18])[C:15]([O:17][CH2:22][CH3:23])=[O:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 702Ethanol2회HCID 3342FenoprofenHCID 14798Sodium Hydroxide

생성물 1

HCID 13585021Fenoprofen Ethyl Ester

실험 절차

Two hundred grams of 2-(3-phenoxyphenyl)propionic acid, prepared according to Example 2, were dissolved in 1500 ml. of ethanol, and hydrogen chloride gas was passed into the ethanolic solution until it was saturated. The reaction mixture was then refluxed with stirring overnight after which a large portion of the ethanol was evaporated in vacuo, and the remaining reaction mixture was poured into ice water. The reaction mixture was basified with 10 percent sodium hydroxide, and extracted twice with ethyl ether. The combined ether extracts were washed twice with water and dried over sodium sulfate. The ethyl ether was evaporated, leaving crude ethyl 2-(3-phenoxyphenyl)propionate as an oily residue. The preparation was repeated with an additional 200 g. of 2-(3-phenoxyphenyl)propionic acid. The crude residues were combined and distilled through a 15 cm. Vigreux column to yield 339.9 g. of ethyl 2-(3-phenoxyphenyl)propionate, b.p., 128°-134° C./0.15 mm., nD25 = 1.5458.

후처리

  1. dissolutionwere dissolved in 1500 ml
  2. temperatureThe reaction mixture was then refluxed
  3. customwas evaporated in vacuo
  4. customthe remaining reaction mixture
  5. extractionextracted twice with ethyl ether
  6. washThe combined ether extracts were washed twice with water
  7. dry with materialdried over sodium sulfate
  8. customThe ethyl ether was evaporated

출처 및 근거

ORD 기록
ord-e00dd4977d934938b8358f239f951228
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04145557

연결된 노트

불러오는 중…