Hydrochloric Acid → Norfloxacin hydrochloride

HRID 614907

반응식

HRID 614907 반응식
O.O.O.O.O.[CH2:6]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]1)[CH3:7].C(N1C2C(=CC(F)=C(N3CCNCC3)C=2)C(=O)C(C(O)=O)=C1)C.[ClH:52]>C(O)C>[ClH:52].[CH2:6]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]1)[CH3:7]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4539NorfloxacinHCID 70603524HCID 70603524, 화합물

생성물 1

HCID 12733888Norfloxacin hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The compound (I) or (II) was dissolved in ethanol and acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with ethanol, and dried to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III) as colorless needles, m.p. above 300° C.

후처리

  1. customThe resulting precipitate was collected
  2. washwashed with ethanol
  3. customdried

출처 및 근거

ORD 기록
ord-9db6c02d96a74a82888d23a4fe2324b2
출처 데이터셋
uspto-grants-1979_03
특허 번호
US04146719

연결된 노트

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