Pyridine → 2-bromo-2,3-dihydro-1H-indene

HRID 615693

반응식

HRID 615693 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1O.N1C=CC=CC=1.P(Br)(Br)[Br:18]>C(Cl)(Cl)Cl>[Br:18][CH:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24614Phosphorus tribromideHCID 779362-Indanol

생성물 1

HCID 109654632-bromo-2,3-dihydro-1H-indene

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

To 80 gms of 2-indanol in 200 ml of chloroform was added 12 ml of pyridine. The solution was cooled to 0° C. with an ice bath, and 64 ml of phosphorous tribromide slowly added over 30 minutes. The ice bath was removed, and the solution was refluxed for 1 hour, and let stand overnight.

후처리

  1. customThe ice bath was removed
  2. temperaturethe solution was refluxed for 1 hour

출처 및 근거

ORD 기록
ord-b54c7438a02d4835acdf095dca28bab3
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04500713

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