Pyridine → 4-Methoxy-5-(2-methoxyethoxy)-(3-nitrophenyl)aminobenzamide

HRID 61664

반응식

HRID 61664 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1C=CC=CC=1.[N+:24]([C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=1)C(Cl)=O)([O-:26])=[O:25]>C(Cl)(Cl)Cl>[CH3:12][O:11][C:9]1[C:8]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([NH:1][C:34]2[CH:33]=[CH:29][CH:28]=[C:27]([N+:24]([O-:26])=[O:25])[CH:35]=2)[CH:10]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8495Benzoyl chloride, 3-nitro-HCID 593619522-Amino-4-methoxy-5-(2-methoxyethoxy)benzamide

생성물 1

HCID 668250844-Methoxy-5-(2-methoxyethoxy)-(3-nitrophenyl)aminobenzamide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a mixture of 2-amino-4-methoxy-5-(2-methoxyethoxyl)benzamide (1.78 g, 7.40 mmol) and pyridine (2.40 mL, 29.6 mmol) in CHCl3 (40 mL) was added 3-nitrobenzoyl chloride (1.44 g, 7.8 mmol). The mixture was stirred at RT for 2.5 h upon which the mixture was concentrated in vacuo to give the desired product, which was used directly in the next step without purification.

후처리

  1. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-3b92ce2d54f94a298ff3bbf4bdd5e07d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440961B2

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