Dimethylformamide → 6-Ethyl-1H-indole-3-carbaldehyde

HRID 618130

반응식

HRID 618130 반응식
P(Cl)(Cl)(Cl)=O.[CH2:6]([C:8]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][CH:9]=1)[CH3:7].[OH-].[Na+].CN(C)[CH:21]=[O:22]>>[CH2:6]([C:8]1[CH:16]=[C:15]2[C:11]([C:12]([CH:21]=[O:22])=[CH:13][NH:14]2)=[CH:10][CH:9]=1)[CH3:7]

참가 물질

5

반응물 4

HCID 6228Dimethylformamide2회HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 183302676-ethyl-1H-indole

생성물 1

HCID 218501566-Ethyl-1H-indole-3-carbaldehyde

실험 절차

Phosphorus oxychloride (3.82 g) was added to N,N-dimethylformamide (20 ml), and the mixture was stirred at room temperature for 10 minutes. A solution of 6-ethylindole [Journal of the Chemical Society (J. Chem. Soc.), 7165 (1965)] in N,N-dimethylformamide (6 ml) was added to the reaction solution, and the mixture was stirred at room temperature for one hour. Ice (20 g) and then a 5N aqueous solution of sodium hydroxide (34 ml) were added to the reaction solution, and the mixture was heated under reflux for one hour. The reaction solution was ice-cooled, and the precipitated crystals were collected by filtration to give 6-ethylindole-3-carboxaldehyde (2.76 g).

후처리

  1. stirringthe mixture was stirred at room temperature for one hour
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for one hour
  4. temperaturecooled
  5. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-20a4dc9d96584dd39f0523e402c8b79a
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952355

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