Indole → 1-(2,2-diethoxyethyl)-1H-indole

HRID 618564노트

반응식

HRID 618564 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[H-].[Na+].[CH2:12]([O:14][CH:15]([O:18][CH2:19][CH3:20])[CH2:16]Br)[CH3:13].O>CS(C)=O>[CH2:12]([O:14][CH:15]([O:18][CH2:19][CH3:20])[CH2:16][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1)[CH3:13]

참가 물질

6

반응물 4

HCID 798IndoleHCID 962WaterHCID 24758Sodium hydrideHCID 74852Ethane, 2-bromo-1,1-diethoxy-

생성물 1

HCID 220130691-(2,2-diethoxyethyl)-1H-indole

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

To a solution of 12 g of indole in 100 ml of dimethyl sulfoxide was added 6.5 g of sodium hydride at room temperature. The mixture was stirred at the same temperature for 1 hour, and 20 ml of bromoacetaldehyde diethyl acetal was added thereto, followed by further stirring at 50° C. for 1 hour. After cooling, the reaction mixture was poured into water, and the product was extracted with ethyl ether. The organic layer was dried over anhydrous magnesium sulfate and concentrated to give 23 g of the title compound.

후처리

  1. stirringby further stirring at 50° C. for 1 hour
  2. temperatureAfter cooling
  3. extractionthe product was extracted with ethyl ether
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c73b62df06bc4bacbbb239556889a14b
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952511

반응 노트

불러오는 중…