Potassium Carbonate → 4-(N-4-hydroxybutyl-N-butylamino)benzaldehyde

HRID 6200

반응식

HRID 6200 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH2:10]([NH:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[OH:19][CH2:18][CH2:17][CH2:16][CH2:15][N:14]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 206691-Butanol, 4-(butylamino)-HCID 680234-Fluorobenzaldehyde

생성물 1

HCID 197950944-(N-4-hydroxybutyl-N-butylamino)benzaldehyde

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
95 °C

실험 절차

To a three neck flask fitted with a mechanical stirrer, a thermometer, and a condenser, is added 124 g (1 mole) of 4-fluorobenzaldehyde, 145.3 g (1 mole) of N-butyl-N-4-hydroxybutylamine, 138.2 g (1 mole) of anhydrous potassium carbonate, and dimethylsulfoxide. The mixture is then heated at 95° C. until the reaction is complete. After cooling to room temperature, the solution is poured into a four-fold excess of ice water, and the solid product is collected by filtration and purified by recrystallization from tetrahydrofuran/benzene.

후처리

  1. customTo a three neck flask fitted with a mechanical stirrer
  2. temperatureAfter cooling to room temperature
  3. filtrationthe solid product is collected by filtration
  4. custompurified by recrystallization from tetrahydrofuran/benzene

출처 및 근거

ORD 기록
ord-4683026ba7114d0ab4a570be14f1d8a7
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05247042

연결된 노트

불러오는 중…