Ammonia → 1-Isopropyl-2-chloromethylbenzimidazole

HRID 620028노트

반응식

HRID 620028 반응식
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11])([CH3:3])[CH3:2].[Cl:12][CH2:13][C:14](O)=O.N>Cl>[CH:1]([N:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:11]=[C:14]1[CH2:13][Cl:12])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 300Chloroacetic AcidHCID 105587871-N-(propan-2-yl)benzene-1,2-diamine

생성물 1

HCID 212484181-Isopropyl-2-chloromethylbenzimidazole수율 64.5%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

N-isopropyl-o-phenylenediamine (2.8 g, 18.6 mmol), which is a known compound, was reacted with monochloroacetic acid (2.64 g, 28 mmol) in hydrochloric acid. The reaction mixture was made to weak by alkaline alkali with aqueous ammonia and the obtained oily material was refined in a usual manner to give the title intermediate (2.5 g, 12 mmol).

출처 및 근거

ORD 기록
ord-9a9dcfe126da47e186ba1a05709c8a76
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818761

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