Hydrochloric Acid → 3,4-Dimethoxycinnamohydroxamic acid

HRID 620406

반응식

HRID 620406 반응식
Cl.[NH2:2][OH:3].[OH-].[K+].[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH:11]=[CH:12][C:13](OC)=[O:14].Cl>CO>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH:11]=[CH:12][C:13]([NH:2][OH:3])=[O:14]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 94307Methyl 3,4-dimethoxycinnamateHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 329133,4-Dimethoxycinnamohydroxamic acid수율 84%

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
0 °C

실험 절차

A solution of hydroxylamine hydrochloride (5.09 g, 72 mmol) in methanol (26 ml) was added to a solution of 88% potassium hydroxide (6.99 g, 109 mmol) in methanol (15.3 ml), keeping the temperature below 40° C. The mixture was cooled to 0° C., filtered, and methyl 3,4-dimethoxycinnamate (8.0 g, 36 mmol) was added to the filtrate. After two hours, concentrated HCl (5 ml) was added to the cold solution. The resulting precipitate was filtered, washed with water and ether, and dried in vacuo, to give 6.74 g (84% yield) of the named compound, mp 183°-185° C.

후처리

  1. customthe temperature below 40° C
  2. filtrationfiltered
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water and ether
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-0ccc845c683e4ffc8d6174324d73e56a
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04820828

연결된 노트

불러오는 중…