Hydrochloric Acid → 2-(p-Nitrophenoxy)-myristic acid

HRID 620702노트

반응식

HRID 620702 반응식
C([O:3][C:4](=[O:28])[CH:5]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])C.C(OC(=O)C(OC1C=CC=C([N+]([O-])=O)C=1)CCCCCCCCCCCC)C.[OH-].[Na+].Cl>C(O)C>[N+:25]([C:22]1[CH:21]=[CH:20][C:19]([O:18][CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:4]([OH:28])=[O:3])=[CH:24][CH:23]=1)([O-:27])=[O:26]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14122414Ethyl 2-(3-nitrophenoxy)tetradecanoateHCID 54095639Ethyl 2-(4-nitrophenoxy)tetradecanoate

생성물 1

HCID 37465002-(p-Nitrophenoxy)-myristic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 980 g of 2-(p-nitrophenoxy)-myristic acid ethyl ester (synthesized analogously to the 2-(m-nitrophenoxy)-myristic acid ethyl ester of Preparation 1), 375 ml of 10N sodium hydroxide, and 1500 ml of ethanol is stirred for 1 h at room temperature and next acidified with 5000 ml of 1N hydrochloric acid. The resulting precipitate is filtered off, rinsed with water until neutral, and dried. The product (845 g) was recrystallized from n-hexane.

후처리

  1. filtrationThe resulting precipitate is filtered off
  2. washrinsed with water until neutral, and
  3. customdried
  4. customThe product (845 g) was recrystallized from n-hexane

출처 및 근거

ORD 기록
ord-a866a4cb93004cd1b249373b89c0efd7
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822729

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