Methyl isothiocyanate → HCID 21242849, 화합물

HRID 621418

반응식

HRID 621418 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[CH3:16][N:17]=[C:18]=[S:19]>C(Cl)(Cl)Cl>[CH3:16][NH:17][C:18]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1)=[S:19]

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 135581517-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione

생성물 1

HCID 21242849HCID 21242849, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

1.3 g. (6.3 mmol) 7-Amino-4,4-dimethyl-isoquinolin-1,3-dione were dissolved in 30 ml. chloroform, mixed with 1.4 g. methyl isothiocyanate and boiled under reflux for 6 hours. The reaction mixture was then cooled and the precipitate was filtered off with suction and recrystallised from ethanol. Yield: 0.8 g. (46% of theory); m.p. 206°-207° C.

후처리

  1. temperatureunder reflux for 6 hours
  2. temperatureThe reaction mixture was then cooled
  3. filtrationthe precipitate was filtered off with suction
  4. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-92272c8f848e4bf7884f58dfbe690085
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824835

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