Ethyl Acetoacetate → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate

HRID 621783노트

반응식

HRID 621783 반응식
[C:1]([O:7][CH2:8]C)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[C:10](OC)(=O)[CH2:11][SH:12].[Na]>ClCCl>[OH:4][C:3]1[CH:5]=[C:11]([CH3:10])[S:12][C:2]=1[C:1]([O:7][CH3:8])=[O:6]

참가 물질

5

반응물 3

HCID 8868Ethyl AcetoacetateHCID 16907Methyl ThioglycolateHCID 5360545Sodium

생성물 1

HCID 587860Methyl 3-hydroxy-5-methylthiophene-2-carboxylate수율 52.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Prepared by the method described in Example 1 from ethyl acetoacetate (130 g, 1.0 mole), methyl thioglycolate (212 g, 2.0 moles) and sodium (53 g, 2.3 moles). The crude product is shaken with two portions of dichloromethane, filtered, and the filtrate stripped of solvent under reduced pressure to afford the product (90.1 g); mp 50°-53° C.

후처리

  1. customPrepared by the method
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-a0d5afd534c549998c46e0ca23cb59e2
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824958

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