Water → 6-Bromo-2-[2-(diisopropylamino)ethyl]phthalazin-1(2H)-one

HRID 622124

반응식

HRID 622124 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][N:6]=[CH:5]2.[OH-].[K+].Cl.[CH:16]([N:19]([CH:23]([CH3:25])[CH3:24])[CH2:20][CH2:21]Cl)([CH3:18])[CH3:17].O>CS(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:21][CH2:20][N:19]([CH:23]([CH3:25])[CH3:24])[CH:16]([CH3:18])[CH3:17])[N:6]=[CH:5]2

참가 물질

6

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 779422-Chloroethyldiisopropylammonium chlorideHCID 115359186-Bromophthalazin-1(2h)-one

생성물 1

HCID 212933346-Bromo-2-[2-(diisopropylamino)ethyl]phthalazin-1(2H)-one

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

6-Bromophthalazinone (11.2 gm, 0.05 mole) was slurried in 80 ml dimethylsulfoxide. To this was added 22 ml 45% KOH (0.25 mole). After stirring 10 minutes 16 gm 2-(diisopropylamino)ethyl chloride hydrochloride was added and the mixture stirred for 18 hours. A water bath was used to moderate the slightly exothermic reaction (temperature <=25°). Water (100 ml) was added to the reaction mixture, which was then stirred another hour.

후처리

  1. additionwas added
  2. customA water bath was used
  3. customthe slightly exothermic reaction (temperature <=25°)
  4. stirringwas then stirred another hour

출처 및 근거

ORD 기록
ord-8beea11fd514416690c0bd6c6de67784
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04769369

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