Hydrochloric Acid → HCID 136252344, 화합물

HRID 624550노트

반응식

HRID 624550 반응식
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][C:6]([NH:8][CH2:9][C:10]1[CH:31]=[CH:30][C:13]2[NH:14][C:15]3[S:16][C:17]([CH3:29])=[CH:18][C:19]=3[C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)=[N:21][C:12]=2[CH:11]=1)=[O:7].[Li+].[OH-].Cl>C1COCC1.O>[CH3:29][C:17]1[S:16][C:15]2[NH:14][C:13]3[CH:30]=[CH:31][C:10]([CH2:9][NH:8][C:6](=[O:7])[CH2:5][CH2:4][C:3]([OH:32])=[O:2])=[CH:11][C:12]=3[N:21]=[C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[C:19]=2[CH:18]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 136377201HCID 136377201, 화합물

생성물 1

HCID 136252344HCID 136252344, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of N-[2-methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulen-7-ylmethyl]-succinamic acid methyl ester, prepared as described in the previous step, (80 mg, 0.18 mmol) in THF (1.5 mL) was added LiOH (14 mg) in water (0.5 mL). The solution was stirred at room temperature for 3 h, acidified with dilute HCl, and concentrated to dryness. LC-MS: m/z 442 (M+1 of the parent).

후처리

  1. customprepared
  2. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-dc9fb150897f4cc0b7e922bf613d663e
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303041B2

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