Sodium hydride → HCID 66588098, 화합물

HRID 625227

반응식

HRID 625227 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][OH:7].[H-].[Na+].Cl[C:16]1[CH:21]=[C:20]([C:22]2[CH:27]=[C:26]([N:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N+:34]([O-:36])=[O:35])[N:19]=[CH:18][N:17]=1>CN(C=O)C>[N+:34]([C:23]1[CH:24]=[CH:25][C:26]([N:28]2[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]2)=[CH:27][C:22]=1[C:20]1[CH:21]=[C:16]([O:7][CH2:6][C:5]2[CH:8]=[CH:9][CH:10]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:4]=2)[N:17]=[CH:18][N:19]=1)([O-:36])=[O:35]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 676813-(Trifluoromethyl)benzylic alcoholHCID 86705928HCID 86705928, 화합물

생성물 1

HCID 66588098HCID 66588098, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 99 mg of 3-(trifluoromethyl)benzyl alcohol in 2 mL of DMF was added 27 mg of a 50% dispersion of sodium hydride in oil. After 15 min the solution was treated with 150 mg of intermediate 3.1b. After an additional 2 h the reaction mixture was partitioned between water and ethyl acetate. The organic extracts were washed with brine and dried (Na2SO4). The solvent was evaporated to give a yellow syrup that was used directly in the next step.

후처리

  1. customAfter an additional 2 h the reaction mixture was partitioned between water and ethyl acetate
  2. washThe organic extracts were washed with brine
  3. dry with materialdried (Na2SO4)
  4. customThe solvent was evaporated
  5. customto give a yellow syrup that

출처 및 근거

ORD 기록
ord-4969a3e7c00549bbbf2591705a6162b3
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09301951B2

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