1-(2-Hydroxyethyl)piperazine → HCID 57516914, 화합물

HRID 62528노트

반응식

HRID 62528 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([NH:9][CH3:10])=[O:8].[OH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.CCN(C(C)C)C(C)C>CN(C=O)C>[OH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:2]2[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=2)[C:7]([NH:9][CH3:10])=[O:8])[CH2:20][CH2:19]1

참가 물질

5

반응물 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 81531DiisopropylethylamineHCID 442030775-Fluoro-N-methyl-2-nitrobenzamide

생성물 1

HCID 57516914HCID 57516914, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 5-fluoro-N-methyl-2-nitrobenzamide, 1-(2-hydroxyethyl)piperazine, and Hunig's base in 20 mL of DMF was stirred at room temperature over the weekend. The resulting mixture was rotavaped to dryness, and the residue was purified by flash column SF40-150 at 2%-10% MeOH/CH2Cl2. Product came out at 7% MeOH/CH2Cl2. MS(ES) m/e 309 [M+H].

후처리

  1. customthe residue was purified by flash column

출처 및 근거

ORD 기록
ord-925e971aa562492cb85f444030df8fcd
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446034B2

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