Water → 3-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one

HRID 625932

반응식

HRID 625932 반응식
[CH2:1]([O:8][C:9]1[C:10](=[O:16])[NH:11][CH:12]=[C:13]([Br:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17]([O-])([O-])=O.[K+].[K+].IC.O>CN(C=O)C>[CH2:1]([O:8][C:9]1[C:10](=[O:16])[N:11]([CH3:17])[CH:12]=[C:13]([Br:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 674068463-(benzyloxy)-5-bromopyridin-2(1H)-one

생성물 1

HCID 674178603-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one수율 87.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a suspension of 2.51 g (8.96 mmol) 3-benzyloxy-5-bromo-1H-pyridin-2-one and 2.48 g (17.9 mmol) K2CO3 in 45 mL DMF was added 1.12 mL (17.9 mmol) iodomethane at room temperature. After stirring overnight, 150 mL water was added with vigorous stirring causing precipitation of the product which was collected by filtration and dried in vacuo affording 2.3 g (87%) 3-benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one

후처리

  1. stirringwith vigorous stirring
  2. customprecipitation of the product which
  3. filtrationwas collected by filtration
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-6dc501ab7a7043bba1f71557da576b5b
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309199B2

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