Hydrochloric Acid → (4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone

HRID 626144

반응식

HRID 626144 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5](Cl)=[O:6].[Al+3].[Cl-].[Cl-].[Cl-].[Cl:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.Cl>ClCCl>[Cl:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([C:5]([C:4]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([F:1])[CH:3]=2)=[O:6])=[CH:23][CH:22]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 12156Benzene, (2-chloroethoxy)-HCID 27792553-Fluoro-4-methoxybenzoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 89656203(4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 3-fluoro-4-methoxybenzoyl chloride from the last step and anhydrous AlCl3 (1.30 g, 9.76 mmol) in dry dichloromethane (18 mL) was added (2-chloroethoxy)benzene (1.53 g, 9.76 mmol) in 2 mL dichloromethane at 0° C. After stirring at rt for 25 min, the mixture was poured into 3 N HCl. The mixture was extracted with dichloromethane. The extract was washed with sat. NaHCO3 and brine, dried over Na2SO4, filtered, and concentrated to give the subtitle compound, which would be used for the next step directly.

후처리

  1. extractionThe mixture was extracted with dichloromethane
  2. washThe extract was washed with sat. NaHCO3 and brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c756a8092d5f4cbbbcfb12df486ac58f
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309211B2

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