Hydrochloric Acid → 4-Chloro-3,5-diisopropoxybenzoic acid

HRID 62751노트

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HRID 62751 반응식
[Cl:1][C:2]1[C:11]([O:12][CH:13]([CH3:15])[CH3:14])=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:16][CH:17]([CH3:19])[CH3:18].[OH-].[Na+].Cl>>[Cl:1][C:2]1[C:11]([O:12][CH:13]([CH3:14])[CH3:15])=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:16][CH:17]([CH3:19])[CH3:18]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67041833Methyl 4-chloro-3,5-diisopropoxybenzoate

생성물 1

HCID 670418114-Chloro-3,5-diisopropoxybenzoic acid수율 68.8%

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온도
100 °C

실험 절차

Methyl 4-chloro-3,5-diisopropoxybenzoate (5) (93 mg, 0.32 mmol) was suspended in 2M sodium hydroxide (1.6 mL, 3.2 mmol) and stirred at 100° C. for 3 h. After cooling to RT the mixture was acidified by the addition of 1 M HCl. The resulting precipitate was collected by filtration and dried in vacuo to afford 4-chloro-3,5-diisopropoxybenzoic acid (6) (60 mg, 66% yield) as a white solid. This material was used in the subsequent reaction step without purification.

후처리

  1. temperatureAfter cooling to RT the mixture
  2. filtrationThe resulting precipitate was collected by filtration
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-9c3a79757fb14569bc674a86fcea72ca
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447028B2

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