2-Propanethiol → 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester

HRID 62858

반응식

HRID 62858 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7](Br)[N:6]=1)=[O:4].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:18][CH:19]([SH:21])[CH3:20]>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:21][CH:19]([CH3:20])[CH3:18])[N:6]=1)=[O:4]

참가 물질

5

반응물 3

HCID 63642-PropanethiolHCID 10796Cesium carbonateHCID 16217886Methyl 6-bromopyridine-2-carboxylate

생성물 1

HCID 901182976-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester수율 89.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).

후처리

  1. customAfter the termination of the reaction
  2. filtrationthe reactant was filtered
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-792a4140021c4e56b730b7d41a6c301c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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