2-Propanethiol → 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester
반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7](Br)[N:6]=1)=[O:4].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:18][CH:19]([SH:21])[CH3:20]>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:21][CH:19]([CH3:20])[CH3:18])[N:6]=1)=[O:4]참가 물질
5
실험 절차
6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).
후처리
- customAfter the termination of the reaction
- filtrationthe reactant was filtered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-792a4140021c4e56b730b7d41a6c301c
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447044B2
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