Water → (2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol

HRID 62869

반응식

HRID 62869 반응식
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH:13]([CH3:15])[CH3:14])[N:7]=1)=O)C.[BH4-].[Na+].O>CO>[CH:13]([S:12][C:8]1[N:7]=[C:6]([CH2:4][OH:3])[CH:11]=[CH:10][N:9]=1)([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 901183312-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester

생성물 1

HCID 90118246(2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol수율 77.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

After 2-isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester (0.1 g, 0.44 mmol) obtained in Step B was dissolved in MeOH (4 mL), NaBH4(0.033 g, 0.9 mmol) was added to the solution, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was added with water, and then extracted with EtOAc. The separated organic layer was dried with MgSO4 and separated by column chromatography to obtain the title compound (0.063 g, 77%).

후처리

  1. customAfter the termination of the reaction
  2. extractionextracted with EtOAc
  3. dry with materialThe separated organic layer was dried with MgSO4
  4. customseparated by column chromatography

출처 및 근거

ORD 기록
ord-b31d92927b9e4c29b9f49751a7272251
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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