Hydrochloric Acid → 2-Isopropylsulfanyl-5-methyl-nicotinic acid

HRID 62875노트

반응식

HRID 62875 반응식
[CH:1]([S:4][C:5]1[C:10]([C:11]#N)=[CH:9][C:8]([CH3:13])=[CH:7][N:6]=1)([CH3:3])[CH3:2].[OH-:14].[K+].Cl.[OH2:17]>CS(C)=O>[CH:1]([S:4][C:5]1[N:6]=[CH:7][C:8]([CH3:13])=[CH:9][C:10]=1[C:11]([OH:17])=[O:14])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 901181222-Isopropylsulfanyl-5-methyl-pyridine-3-carbonitrile

생성물 1

HCID 901181832-Isopropylsulfanyl-5-methyl-nicotinic acid수율 73%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

After 2-isopropylsulfanyl-5-methyl-pyridine-3-carbonitrile (0.186 g, 0.97 mmol) obtained in Step A was dissolved in water (0.4 mL) and DMSO (0.04 mL), KOH (0.76 g) was added thereto, and the mixture was stirred at 100° C. for 16 hours. After the termination of the reaction, 6N HCl aqueous solution was added thereto to adjust the pH of the reactant to 2, and the mixture was extracted with EtOAc. The organic layer was separated, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.15 g, 73%).

후처리

  1. additionwas added
  2. extractionthe mixture was extracted with EtOAc
  3. customThe organic layer was separated
  4. dry with materialdried with MgSO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3b6193eb6f9940cfa0ee8459627dd774
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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