Acetic Anhydride → 8-Bromo-1,2,3,4-tetrahydronaphthalen-1-ol

온도

-20 °C

To a mixture of 78.5 g (530 mmol) of 1,2,3,4-tetrahydronaphthalen-1-ol, 160 ml (1.06 mol) of TMEDA, and 3000 ml of pentane cooled to −20° C. 435 ml (1.09 mol) of 2.5M nBuLi in hexanes was added dropwise. The obtained mixture was refluxed for 12 h. To the resulting mixture cooled to −80° C. 160 ml (1.33 mol) of 1,2-dibromotetrafluoroethane was added, and this mixture was allowed to warm to room temperature and then stirred for 12 h at this temperature. After that 100 ml of water was added. The resulting mixture was diluted with 2000 ml of water, and the organic layer was separated. The aqueous layer was extracted with 3×400 ml of toluene. The combined organic extract was dried over Na2SO4 and evaporated to dryness. The residue was distilled using the Kugelrohr apparatus, b.p. 150-160° C./1 mbar. The resulting yellow oil was dissolved in 100 ml of triethylamine, and the obtained solution was added dropwise to a stirred solution of 71.0 ml (750 mmol) of acetic anhydride and 3.00 g (25.0 mmol) of DMAP in 105 ml of triethylamine. The resulting mixture was stirred for 5 min, then 1000 ml of water was added, and the obtained mixture was stirred for 12 h. After that the reaction mixture was extracted with 3×200 ml of ethyl acetate. The combined organic extract was washed with aqueous Na2CO3, dried over Na2SO4, and evaporated to dryness. The residue was purified by flash chromatography on silica gel 60 (40-63 um, eluent: hexane-ethyl acetate=30:1, vol.). The resulting acetate was dissolved in 1500 ml of methanol, 81.0 g (1.45 mol) of KOH was added, and the obtained mixture was refluxed for 3 h. The reaction mixture was then cooled to room temperature and poured into 4000 ml of water, and the title product was extracted with 3×300 ml of dichloromethane. The combined organic extract was dried over Na2SO4 and then evaporated to dryness. Yield 56.0 g (47%) of a white crystalline solid. Anal. Calc for C10H11BrO: C, 52.89; H, 4.88. Found: C, 53.01; H, 4.75. 1H NMR (CDCl3): δ 7.38-7.41 (m, 1H, 7-H); 7.03-7.10 (m, 2H, 5,6-H); 5.00 (m, 1H, 1-H), 2.81-2.87 (m, 1H, 4- or 4′-H), 2.70-2.74 (m, 1H, 4′- or 4-H), 2.56 (br.s., 1H, OH), 2.17-2.21 (m, 1H, 2- or 2′-H), 1.74-1.79 (m, 2H, 3,3′-H).

1. temperatureThe obtained mixture was refluxed for 12 h
2. temperatureTo the resulting mixture cooled to −80° C
3. temperatureto warm to room temperature
4. customthe organic layer was separated
5. extractionThe aqueous layer was extracted with 3×400 ml of toluene
6. extractionThe combined organic extract
7. dry with materialwas dried over Na2SO4
8. customevaporated to dryness
9. distillationThe residue was distilled
10. dissolutionThe resulting yellow oil was dissolved in 100 ml of triethylamine
11. stirringThe resulting mixture was stirred for 5 min
12. stirringthe obtained mixture was stirred for 12 h
13. extractionAfter that the reaction mixture was extracted with 3×200 ml of ethyl acetate
14. extractionThe combined organic extract
15. washwas washed with aqueous Na2CO3
16. dry with materialdried over Na2SO4
17. customevaporated to dryness
18. customThe residue was purified by flash chromatography on silica gel 60 (40-63 um, eluent: hexane-ethyl acetate=30:1, vol.)
19. dissolutionThe resulting acetate was dissolved in 1500 ml of methanol
20. temperaturethe obtained mixture was refluxed for 3 h
21. temperatureThe reaction mixture was then cooled to room temperature
22. extractionthe title product was extracted with 3×300 ml of dichloromethane
23. extractionThe combined organic extract
24. dry with materialwas dried over Na2SO4
25. customevaporated to dryness

ORD 기록

ord-d5d8bcd6e43741b2b36c653f70d818a1

출처 데이터셋

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09315593B2