Chloroacetic Acid → 5,6-Dimethyluracil

HRID 63094

반응식

HRID 63094 반응식
[CH3:1][C:2]1[C:3](=[O:10])[NH:4][C:5](=S)[NH:6][C:7]=1[CH3:8].ClCC(O)=[O:14]>O>[CH3:1][C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:14])[NH:6][C:7]=1[CH3:8]

참가 물질

4

반응물 2

HCID 300Chloroacetic AcidHCID 27362495,6-Dimethyl-2-thiouracil

생성물 1

HCID 960315,6-Dimethyluracil수율 81.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 5,6-dimethyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (14.4 g, 0.09 mol, Step A) and chloroacetic acid (100.0 g, 1.06 mol) in water (43 mL) was refluxed overnight, cooled down to ambient temperature and quenched with water (500 mL). The formed precipitate was collected by filtration and dried to yield 10.3 g (79.7%) of the titled compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.70 (s, 3H) 2.02 (s, 3H) 10.56 (s, 1H) 10.86 (s, 1H).

후처리

  1. customquenched with water (500 mL)
  2. filtrationThe formed precipitate was collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-1cf59a9992694d7bb67f93f1ff275d11
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447051B2

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