Lithium hydroxide, monohydrate → HCID 6102685, 화합물

HRID 631872노트

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HRID 631872 반응식
C[O:2][C:3]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][C:6]=1[NH:15][S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])=[O:17])=[O:4].O.[OH-].[Li+]>O1CCOCC1.O.Cl>[C:19]1([S:16]([NH:15][C:6]2[CH:7]=[CH:8][C:9]3[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=3[C:5]=2[C:3]([OH:4])=[O:2])(=[O:18])=[O:17])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

6

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 68296414HCID 68296414, 화합물2회

생성물 1

HCID 6102685HCID 6102685, 화합물

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 962Water용매HCID 312751,4-Dioxane용매

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온도
160 °C

실험 절차

2-Benzenesulfonylamino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (Intermediate 4, 0.68 g) was dissolved in dioxane (12 mL) and a solution of lithium hydroxide monohydrate (0.6 g) in water (6 mL) was added. The mixture was heated by microwave irradiation at 160° C. for 15 minutes then diluted with 1N hydrochloric acid. The product was extracted into DCM and the organic solution was separated, dried with magnesium sulfate, filtered and the filtrate was concentrated under vacuum to give the title compound as a white powder.

후처리

  1. extractionThe product was extracted into DCM
  2. customthe organic solution was separated
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-fa8d3775e09b43e495bea60c20e989b5
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321740B2

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