Cyclohexanemethanol → 2-(Cyclohexylmethoxy)pyrimidine

HRID 63351

반응식

HRID 63351 반응식
[H-].[Na+].Br[C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[CH:10]1([CH2:16][OH:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>C1COCC1>[CH:10]1([CH2:16][O:17][C:4]2[N:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 7507CyclohexanemethanolHCID 24758Sodium hydrideHCID 783452-Bromopyrimidine

생성물 1

HCID 866946672-(Cyclohexylmethoxy)pyrimidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

NaH (1.1 equivalent) is added to an equimolar mixture of 2-bromopyrimidine and cyclohexylmethanol in THF. The reaction mixture is stirred at +60° C. for 18 hours, cooled to room temperature, partitioned between H2O and ethyl acetate. Organic portion is separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)pyrimidine.

후처리

  1. custompartitioned between H2O and ethyl acetate
  2. customOrganic portion is separated
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-08bcb063c6f745de8323dde4cf803480
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447078B2

연결된 노트

불러오는 중…