Hydrogen Bromide → 2-Bromo-1-(6-methylpyridin-3-yl)ethanone hydrobromide

HRID 633747

반응식

HRID 633747 반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[BrH:11].BrBr>C(O)(=O)C>[BrH:11].[Br:11][CH2:9][C:8]([C:5]1[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=1)=[O:10]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 952923-Acetyl-6-methylpyridine

생성물 1

HCID 454805112-Bromo-1-(6-methylpyridin-3-yl)ethanone hydrobromide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

500 mg (3.59 mmol) of 1-(6-methylpyrid-3-yl)ethanone, 590 μl (3.59 mmol) of hydrobromic acid, 204 μl (3.95 mmol) of bromine and 10 mL of glacial acetic acid were used in the reaction. After precipitation with ethyl ether and filtration, 1.02 g of 2-bromo-1-(6-methylpyrid-3-yl)ethanone hydrobromide are obtained, the characteristics of which are as follows:

후처리

  1. customAfter precipitation
  2. filtrationwith ethyl ether and filtration, 1.02 g of 2-bromo-1-(6-methylpyrid-3-yl)ethanone hydrobromide
  3. customare obtained

출처 및 근거

ORD 기록
ord-eee58b6607064dc58e5a858551127640
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321790B2

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