Hydrochloric Acid → 2-(1-Pyrrolidinyl)-3-pyridinol

반응식

Br[C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1.Cl>>[N:9]1([C:2]2[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 230702-Bromo-3-pyridinol

HCID 31268Pyrrolidine

생성물 1

HCID 900023802-(1-Pyrrolidinyl)-3-pyridinol수율 41.3%

실험 절차

2-bromopyridin-3-ol (200 mg, 1.15 mmol) and pyrrolidine (184 mg, 2.58 mmol) were added in a reaction tube, followed by reacting in microwave at 120° C. for 20 minutes. The reaction mixture was added with 1 M HCl solution to neutralized, and extracted with ethyl acetate and dichloromethane. The obtained organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The concentrate was purified by column chromatography to obtain 2-(pyrrolidin-1-yl)pyridin-3-ol (78 mg, 41%).

후처리

extractionextracted with ethyl acetate and dichloromethane
dry with materialThe obtained organic layer was dried over magnesium sulfate
concentrationconcentrated under reduced pressure
customThe concentrate was purified by column chromatography

출처 및 근거

ORD 기록: ord-48275c11308c4f8f9f29ea0f02a7e2d8
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09447083B2

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