홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline hydrochloride

HRID 634737
노트
인쇄 미리보기

반응식

HRID 634737 반응식
[OH-].[Na+].[F:3][C:4]1[CH:28]=[C:27]([CH3:29])[C:26]([O:30]C(OC)=O)=[CH:25][C:5]=1[NH:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([NH:19][C:20](=[O:24])[CH2:21][O:22][CH3:23])=[C:14]([O:17][CH3:18])[CH:15]=2)[N:10]=[CH:9][N:8]=1.[ClH:35]>CO.O>[ClH:35].[F:3][C:4]1[CH:28]=[C:27]([CH3:29])[C:26]([OH:30])=[CH:25][C:5]=1[NH:6][C:7]1[C:16]2[C:11](=[CH:12][C:13]([NH:19][C:20](=[O:24])[CH2:21][O:22][CH3:23])=[C:14]([O:17][CH3:18])[CH:15]=2)[N:10]=[CH:9][N:8]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 107894254-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline

생성물 1

HCID 212602834-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline hydrochloride수율 82%

시약·촉매·용매 2

HCID 887Methanol용매
HCID 962
Water
용매

실험 절차

2M Aqueous sodium hydroxide solution (620 μl) was added dropwise to a suspension of 4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline (275 mg, 0.62 mmol) in methanol (8 ml) at 5° C. and the mixture then stirred for 90 minutes at ambient temperature. The reaction mixture was diluted with water and adjusted to pH7 with 2M hydrochloric acid. The precipitated solid was collected by filtration, resuspended in ethanol and a 5M solution of hydrogen chloride in isopropanol (0.3 ml) added. The volatiles were removed from the resulting solution by evaporation and the solid washed with ether collected by filtration and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-methoxyacetamidoquinazoline hydrochloride (216 mg, 82%).

후처리

  1. filtrationThe precipitated solid was collected by filtration
  2. additiona 5M solution of hydrogen chloride in isopropanol (0.3 ml) added
  3. customThe volatiles were removed from the resulting solution by evaporation
  4. washthe solid washed with ether
  5. filtrationcollected by filtration
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-c83a28a9c46640a182e3a9bcaa415882
출처 데이터셋
uspto-grants-2001_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06184225B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트